National Institute on Deafness and Other Communication Disorders (NIDCD)
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14 checked · 0 open checksOral ORC-13661 small molecule evaluated in a randomized Phase 2 dose-ranging trial to prevent or mitigate IV amikacin-associated ototoxic hearing loss in adults with nontuberculous mycobacterial disease.
Completed multicenter Phase 3 non-inferiority trial comparing intratympanic methylprednisolone sodium succinate injections with oral prednisone for idiopathic sudden sensorineural hearing loss.
Image-guided cochlear implant programming workflow using pre- and post-implant CT image processing, cochlear segmentation, electrode localization, and clinical software adjustments to optimize stimulus delivery in pediatric CI recipients.
Basic-science study experimentally changing cochlear implant stimulation parameters to measure electrically evoked compound action potentials in implanted participants with Usher syndrome or idiopathic hearing loss.
Oral micronutrient combination of beta-carotene, vitamins C and E, and magnesium tested for prevention of temporary music-induced threshold shifts/noise-induced hearing changes.
Randomized double-blind trial evaluating gabapentin for relief of idiopathic subjective tinnitus.
Recruiting NYU study evaluating alternative cochlear-implant frequency allocation tables in newly implanted single-sided deaf cochlear implant users to reduce place-pitch mismatch and improve sound quality, device use, and speech perception.
Investigator-led Phase 1/2 studies of subcutaneous anakinra/Kineret in corticosteroid-resistant autoimmune inner ear disease and sudden sensorineural hearing loss.
Oral atorvastatin 40 mg daily during and after cisplatin-based chemoradiation, evaluated for reduction of cisplatin-induced hearing loss in adults with head and neck squamous cell carcinoma.
Institution-led study presenting sound stimuli under experimental conditions that simulate hearing-aid configurations, styles, or processing strategies to assess spatial perception and speech understanding.
Observational age-related hearing study that captured hormone replacement therapy exposure while evaluating neural and psychoacoustic changes in the aging auditory system.
Terminated Phase 3 NIDCD study involving corticosteroids and methotrexate in sensorineural hearing loss associated with autoimmune inner ear disease.