Details checkedClinical trial listing onlyHistorical/discontinuedCheckedregistry-results+publication

University of Michigan Soundbites micronutrient NIHL prevention study

Also known as: Beta-Carotene, Vitamins C And E, Magnesium, Soundbites, Soundbites dietary supplement, Micronutrients to Prevent Noise-induced Hearing Loss, NCT00808470, U01DC008423

Institution-led study

Primary source

Sponsor / Institution

Institution-led study

Program Type

Therapeutic

Modality

Small Molecule

Stage

Phase 2

Status

Completed

Target Gene

—

Route / Mode

Oral dietary supplement tablets

Confidence

86%

Status Confidence

Status needs checking

Evidence Strength

Needs more support

Last Reviewed

2026-06-09

Geography

United States

Population

adult, healthy-volunteer, noise-induced, otoprotection, dietary-supplement

Trial IDs

Mechanism

Oral micronutrient combination of beta-carotene, vitamins C and E, and magnesium tested for prevention of temporary music-induced threshold shifts/noise-induced hearing changes.

Indications

Hearing Loss Noise-Induced Hearing Loss Tinnitus

Notes

Corrected from an EuHearing-owned row. ClinicalTrials.gov lists University of Michigan as lead sponsor and Hearing Health Science, Inc. as an unknown-class collaborator. Results are posted, and the cited Audiology & Neurotology Extra publication reports failure to prevent music-induced temporary threshold shift.

Evidence & Sources

2 structured sources

clinicaltrials

Supports: canonicalName, aliases, allCompanies, isIndustrySponsored, stage, status, route, indications...

IDs: NCT00808470, U01DC008423, Soundbites

Open

publication

Supports: status, notes, keyEvents

IDs: PMID:27990155

Open

Key Events

2008-12-15