Therapies database

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6 results

Therapy	Approach	Progress	Population	Additional Info
Otarmeni by RegeneronRegeneron Pharmaceuticals Compare	Gene Therapy	Stage: ApprovedStatus: Approved	Children & adults · FDA label has no age bounds; trial: 10 months–16 yearsBiallelic OTOF severe-to-profound deafness
AK-OTOF by Eli Lilly and AkouosEli Lilly and Company Compare	Gene Therapy	Stage: Phase 2Status: Active	Children & adults · Cohort-specific; no overall age limitBiallelic OTOF profound bilateral auditory neuropathy
SENS-501 by SensorionSensorion Compare	Gene Therapy	Stage: Phase 1/2Status: Active	Children · 6–31 monthsBiallelic OTOF deafness with preserved outer-hair-cell function
Rincell-1 by Rinri TherapeuticsRinri Therapeutics Compare	Cell Therapy	Stage: Phase 1/2Status: Active	Adults · 18–74 yearsCochlear-implant candidates with presbycusis or auditory neuropathy
ReSonance by Lineage Cell TherapeuticsLineage Cell Therapeutics Compare	Cell Therapy	Stage: PreclinicalStatus: Active	Children & adults · Not yet defined (preclinical)Auditory neuropathy spectrum disorders
EHT102 by EuHearingShanghai EuHearing Therapeutics Co., Ltd Compare	Gene Therapy	Stage: Phase 1/2Status: Active	Children · 1–17 yearsBiallelic OTOF DFNB9 severe-to-profound deafness

Otarmeni by Regeneron

Regeneron Pharmaceuticals · Gene Therapy · Approved

ApprovedTherapeuticStronger sources

Population

Children & adults · FDA label has no age bounds; trial: 10 months–16 years

Biallelic OTOF severe-to-profound deafness

Evidence

regulatory

Confidence

99%

Indications

Hearing LossSensorineural Hearing LossGenetic Hearing LossOTOF-Related Hearing Loss

AK-OTOF by Eli Lilly and Akouos

Eli Lilly and Company · Gene Therapy · Phase 2

ActiveTherapeuticStronger sources

Population

Children & adults · Cohort-specific; no overall age limit

Biallelic OTOF profound bilateral auditory neuropathy

Evidence

trial

Confidence

95%

Indications

Hearing LossSensorineural Hearing LossGenetic Hearing LossOTOF-Related Hearing Loss

SENS-501 by Sensorion

Sensorion · Gene Therapy · Phase 1/2

ActiveTherapeuticStronger sources

Population

Children · 6–31 months

Biallelic OTOF deafness with preserved outer-hair-cell function

Evidence

trial

Confidence

94%

Indications

Hearing LossSensorineural Hearing LossGenetic Hearing LossOTOF-Related Hearing Loss

Rincell-1 by Rinri Therapeutics

Rinri Therapeutics · Cell Therapy · Phase 1/2

ActiveTherapeuticStronger sources

Population

Adults · 18–74 years

Cochlear-implant candidates with presbycusis or auditory neuropathy

Evidence

trial

Confidence

92%

Indications

Hearing LossSensorineural Hearing LossAge-Related Hearing LossAuditory Neuropathy

ReSonance by Lineage Cell Therapeutics

Lineage Cell Therapeutics · Cell Therapy · Preclinical

ActiveTherapeuticStronger sources

Population

Children & adults · Not yet defined (preclinical)

Auditory neuropathy spectrum disorders

Evidence

company

Confidence

87%

Indications

Hearing LossSensorineural Hearing LossAuditory Neuropathy

EHT102 by EuHearing

Shanghai EuHearing Therapeutics Co., Ltd · Gene Therapy · Phase 1/2

ActiveTherapeutic

Population

Children · 1–17 years

Biallelic OTOF DFNB9 severe-to-profound deafness

Evidence

trial

Confidence

90%

Indications

Hearing LossSensorineural Hearing LossGenetic Hearing LossOTOF-Related Hearing Loss

A listing is not proof of safety or effectiveness. Approval and availability may vary by indication and country.

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