Details checkedClinical trial listing onlyHistorical/discontinuedCheckedregistry

Lactated Ringer's With Ofloxacin Cisplatin Otoprotection Study

Also known as: Lactated Ringer's with Ofloxacin, Lactated Ringers for cisplatin ototoxicity

Institution-led study

Primary source

Sponsor / Institution

Institution-led study

Program Type

Therapeutic

Modality

Drug Delivery

Stage

Phase 1

Status

Discontinued

Target Gene

—

Route / Mode

Topical ear drops

Confidence

71%

Status Confidence

Status needs checking

Evidence Strength

Needs more support

Last Reviewed

2026-06-10

Geography

United States

Population

adult, cisplatin-ototoxicity, study-level

Trial IDs

Mechanism

Withdrawn academic Phase 1 study of topical ear-canal drops containing lactated Ringer's solution with ofloxacin, intended to evaluate protection from cisplatin-associated hearing loss.

Indications

Hearing Loss Cisplatin-Induced Hearing Loss

Notes

ClinicalTrials.gov verifies a withdrawn University of Oklahoma study testing lactated Ringer's with ofloxacin drops for cisplatin ototoxicity protection. This is historical registry evidence only, not a current commercial otoprotective product.

Evidence & Sources

1 structured sources

clinicaltrials

Supports: canonicalName, aliases, company, allCompanies, isIndustrySponsored, programType, modality, mechanism...

IDs: NCT00584155

Open

Key Events

2006-07-01

Registry-listed start of lactated Ringer's with ofloxacin otoprotection study

2010-06-01

Registry-listed actual completion for withdrawn study

Clinical Trials (1)