Therapeutics
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Hadassah Wolfram Syndrome Type 2 Combination Therapy Study

Also known as: Treatment of Wolfram Syndrome Type 2 With the Chelator Deferiprone and Incretin Based Therapy, Deferiprone and acetylcysteine Wolfram syndrome study, Deferiprone acetylcysteine sitagliptin metformin, Ferriprox Reolin Januet, NCT02882477

Institution-led study

Primary source
Sponsor / Institution
Institution-led study
Program Type
Therapeutic
Modality
Small Molecule
Stage
Phase 2
Status
Unknown
Target Gene
CISD2
Route / Mode
Oral
Confidence
84%
Status Confidence
Status needs checking
Evidence Strength
Needs more support
Last Reviewed
2026-06-10
Geography
Israel
Population
genetic, syndromic, pediatric, adult
Trial IDs
1
Mechanism

Academic Phase 2 study evaluating a combination strategy for genetically diagnosed Wolfram syndrome type 2: deferiprone chelation plus acetylcysteine antioxidant therapy, with sitagliptin/metformin added for participants with diabetes. The component drugs are trial arms/components, not separate industry-sponsored hearing-loss pipeline programs.

Indications
Notes

Promoted as a verified registry-backed academic Wolfram syndrome type 2 combination-therapy study while preserving status-unknown and study-level caveats. The component drugs are one Hadassah protocol, not distinct HearScape product programs.

Evidence & Sources
2 structured sources
clinicaltrials
Supports: canonicalName, aliases, company, stage, status, modality, indications, route...
IDs: NCT02882477
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registry mirror
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IDs: NCT02882477, 0003-16-HMO
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Key Events
Clinical Trials (1)
Data Checks
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